abstract：:1. The light/dark paradigm is based on the innate aversion of rodents to brightly illuminated areas and on the spontaneous exploratory behaviour of the animals, applying mild stressors i.e. novel environment and light. The test apparatus consists of a small dark secure compartment (one third) and a large illuminated a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hascoët M,Bourin M,Nic Dhonnchadha BA

更新日期：2001-01-01 00:00:00

abstract：:1. A better understanding of the pathophysiology of AD has been made possible through population-based epidemiological studies, human genetic and post-mortem studies, leading to a number of testable hypothesis towards delaying progression. 2. A number of disease milestones have been identified as therapeutic targets, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gauthier S

更新日期：2001-01-01 00:00:00

abstract：:1. Animal models of human behavior and disease are commonly used and have contributed significantly to progress in understanding the physiological mechanisms of both normal function and disease, and in the development of effective therapies. 2. Little attention has been given, however, to the scientific and ethical im...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bird SJ,Parlee MB

更新日期：2000-11-01 00:00:00

abstract：:1. The role of Gi-proteins on cataleptic responses induced by SCH23390 and haloperidol in chronic cocaine-treated mice was examined by intracerebroventricullor (i.c. v.) and intravenous (i. v.) injections of pertussis toxin (PTX), which catalyzes adenosine diphosphate (ADP)-ribosylation of Gi-proteins. 2. In animals p...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Ushijima I,Mizuki Y,Kobayashi T,Aoki T,Suetsugi M,Usami K,Watanabe Y

更新日期：2000-11-01 00:00:00

abstract：:1. The present study was designed to evaluate the effects of zinc on spatial reference memory and brain dopamine (D1) receptor binding kinetics in rats. Male Sprague-Dawley rats (120-150 g), adapted 12 hour light: 12 hour dark illumination cycle were used. Treated animals were given zinc chloride (25 mg/kg, 50 mg/kg, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Turner TY,Soliman MR

更新日期：2000-10-01 00:00:00

abstract：:1. Patch-clamp technique was used in primary cultures of cerebellar granule neurons to study the modulation of the cyclothiazide analogue (IDRA21) and of the diazoxide derivative (IDRA 5) on KA-evoked currents. 2. The dose-response of kainic acid (KA) reveals an EC50=90 microM and an Hill coefficient of 1.3. IDRA 21 a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Puia G,Losi G,Razzini G,Braghiroli D,Di Bella M,Baraldi M

更新日期：2000-08-01 00:00:00

abstract：:1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting, and the effectiveness persists over repeate...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Siwak CT,Callahan H,Milgram NW

更新日期：2000-07-01 00:00:00

abstract：:1. The use of animal models in certain types of psychobiological studies (for instance, the relationship between anxiety and depression) requires that the behavior measured is stable over time. 2. The test-retest reliability of the elevated plus-maze indexes of anxiety and the immobility time in the behavioral despair...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Andreatini R,Bacellar LF

更新日期：2000-05-01 00:00:00

abstract：:1. Despite increased understanding of the prevalence and pharmacotherapy of social phobia (or social anxiety disorder), the neurobiology of the disorder is little understood. 2. Little data exists on the effect of pharmacotherapeutic intervention on regional cerebral blood flow (rCBF) in this disorder. Patients (n=15)...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Van der Linden G,van Heerden B,Warwick J,Wessels C,van Kradenburg J,Zungu-Dirwayi N,Stein DJ

更新日期：2000-04-01 00:00:00

abstract：:1. The modifications of hippocampal release of norepinephrine following the administration of R-(-)-alpha-methylhistamine and thioperamide, respectively agonist and antagonist of histamine H3 receptors, were assessed in freely moving rats by microdialysis. 2. Both the systemic (2 mg/kg i.p.) and local (100 microM via ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Di Carlo G,Ghi P,Orsetti M

更新日期：2000-02-01 00:00:00

abstract：:Chronic abusers of alcohol and other drugs often exhibit persistent deficits on neuropsychological tests. These deficits are usually attributed to drug-induced brain dysfunction or to familial factors that depress performance independent of drug abuse. The aim of this study was to determine the plausibility of a third...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Beatty WW,Borrell GK

更新日期：2000-01-01 00:00:00

abstract：:1-methyl-4-phenylpyridinium (MPP+) is a drug that induces a Parkinson's-like syndrome in several species. Oxidative stress resulting from either excess generation or reduced scavenging of free radicals has been proposed to play a role in its neurotoxicity. It has been suggested that metallothionein (MT) protects again...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rojas P,Hidalgo J,Ebadi M,Rios C

更新日期：2000-01-01 00:00:00

abstract：:1. To investigate whether abnormalities in objective neurophysiologic measures are observable in patients with probable dissociative generalized amnesia, the P300 and N100 event-related potentials were evaluated in six such patients in both acute stage and after recovery from amnesia. Findings were compared with those...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Fukuzako H,Fukuzaki S,Fukuzako T,Jing H,Ueyama K,Takigawa M

更新日期：1999-11-01 00:00:00

abstract：:1. This study shows that the human cannabinoid receptors and their gene transcripts can be analyzed in blood samples when combined with polymerase chain reaction. The results also demonstrate that the expression of the cannabinoid receptors is dependent on gender and ethnic background. 2. Normal human volunteers who d...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Onaivi ES,Chaudhuri G,Abaci AS,Parker M,Manier DH,Martin PR,Hubbard JR

更新日期：1999-08-01 00:00:00

abstract：:1. The carboxyl terminus of the amyloid precursor protein (APP) has several identified regions that may potentially contribute to the pathogenic effects of Alzheimer's disease (AD). To examine these effects, the authors iodinated a short synthetic peptide corresponding to amino acids 679-687 of APP695. They also produ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Daly J,Lahiri DK,Kotwal GJ

更新日期：1999-07-01 00:00:00

abstract：:1. High-resolution MRI scans were obtained from 35 relatively high-functioning persons with autism and 36 healthy controls, comparable in age, gender, and IQ. 2. Volumetric measurements were obtained from manual tracing of the bilateral caudate, putamen, and globus pallidus. 3. An increased volume of the caudate nucle...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sears LL,Vest C,Mohamed S,Bailey J,Ranson BJ,Piven J

更新日期：1999-05-01 00:00:00

abstract：:1. Male Swiss Webster mice were administered a series of amphetamine injections preceded by either saline or L-DOPA. 2. This injection regimen was performed for either one, two or three consecutive weeks and neurotoxic effects of the drugs were determined one week later. 3. Amphetamine treatment for two weeks produced...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Myers CS,Halladay AK,Widmer DA,Wagner GC

更新日期：1999-05-01 00:00:00

abstract：:1. The authors examined the effect of acute alcohol consumption on a set of visual tasks: visual short term memory, depth perception, and attention. 2. In a repeated measurement design, thirteen subjects performed the tasks once sober and once intoxicated with 0.8 g/kg body weight pure ethanol in orange juice (33% alc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wegner AJ,Fahle M

更新日期：1999-04-01 00:00:00

abstract：:1. The effects exerted by GABAB receptor agonists and antagonists on the acute opiate withdrawal induced by mu and k receptor agonists were investigated in vitro. 2. Following a 4 min in vitro exposure to morphine (less selective mu agonist), DAGO (highly selective mu agonist) and U50-488H (highly selective k agonist)...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Capasso A

更新日期：1999-02-01 00:00:00

abstract：:1. The authors have previously shown that direct activation of metabotropic glutamate receptors (mGluRs) by (S)-3,5-dihydroxyphenylglycine ((S)-DHPG) can induce a long-lasting potentiation of synaptic transmission in the rat dentate gyrus in vitro. Here the authors provide further characterisation of this agonist-indu...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： O'Leary DM,O'Connor JJ

更新日期：1999-01-01 00:00:00

abstract：:1. There is a large body of evidence indicating that fenfluramines damage brain serotonin neurons in animals. 2. Little is known about potential adverse neuropsychiatric consequences in humans associated with use of fenfluramines that could potentially be related to serotonergic dysfunction. 3. The authors now report ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： McCann UD,Eligulashvili V,Ricaurte GA

更新日期：1998-10-01 00:00:00

abstract：:1. During a prospective and outpatient study the correlation between the lithium ratio and the incidence of lithium side effects and type of comedications was studied in 51 Iranian bipolar patients by using new direct method of measuring erythrocyte lithium concentration. 2. Results revealed that patients who received...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Dehpour AR,Emamian ES,Ahmadi-Abhari SA,Azizabadi-Farahani M

更新日期：1998-08-01 00:00:00

abstract：:1. The effect of chronic antidepressant administration on CRE-, SP1- and GRE-binding activity was studied in rat hippocampus and frontal cortex. 2. Fluoxetine and desipramine (3 and 10 mg/kg/day respectively) were given to rats for 21 consecutive days. The animals were killed 3 hr after the last injection and nuclear ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Frechilla D,Otano A,Del Río J

更新日期：1998-07-01 00:00:00

abstract：:1. Male Sprague-Dawley rats (weighing 260-300 g) were administered 1.5 mg/kg of haloperidol (HPD) intraperitoneally once daily for 28 days to produce an animal model for tardive dyskinesia (TD). The daily administration of HPD significantly increased the frequency of involuntary orofacial movements (chewing movements,...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Takeuchi H,Ishigooka J,Kobayashi K,Watanabe S,Miura S

更新日期：1998-05-01 00:00:00

abstract：:1. This study compares behavioral responses to serotonergic (5HT) agonists and pentylenetetrazol (PTZ) in two behavioral paradigms used as animal models of anxiety. PTZ and mCPP were compared for behavioral effects in elevated plus-maze and interoceptive discriminative stimuli they produce. 2. PTZ is a known anxiogeni...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wallis CJ,Lal H

更新日期：1998-04-01 00:00:00

abstract：:1. Disturbances in cortisol secretory patterns and excessive secretion of cortisol after a variety of neuroendocrine stimulation tests indicate excessive activity of the hypothalamic-pituitary-adrenocortical axis in depression. 2. Peripheral indicators of hypercortisolemia have also been observed (e.g. enlarged adrena...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Amsterdam JD,Hooper MB

更新日期：1998-02-01 00:00:00

abstract：:1. This study examines the effects of exercise training and chronic ethanol consumption on cholinesterase activity and its relationship to lipid peroxidation in blood and brain regions of rat. 2. Exercise training (6.5 weeks) decreased acetylcholinesterase (AChE) activity significantly (64% of control) in hypothalamus...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Husain K,Somani SM

更新日期：1998-02-01 00:00:00

abstract：:1. Citicoline (cytidine (5') diphosphocholine) has been shown to reverse aging-induced memory deficits, scopolamine-induced amnesia and nucleus basalis magnocellularis lesion-induced learning impairment. 2. This study aimed to evaluate the effects of citicoline on learning and retrieval processes in a complex differen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bruhwyler J,Liégeois JF,Géczy J

更新日期：1998-01-01 00:00:00

abstract：:1. Alzheimer's Disease (AD) is accompanied by a disruption in iron metabolism. There is no universally accepted method for detecting brain iron. 2. The authors have developed a novel "ratio" method which uses the red nucleus as an internal reference. We postulated that this method would improve our sensitivity in dete...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Parsey RV,Krishnan KR

更新日期：1997-11-01 00:00:00

abstract：:1. To test the hypothesis that lithium-induced body weight gain is related to an unbalance in the reproductive hormones, lithium carbonate (900 mg/day) or placebo was administered to healthy men for 1 month. 2. Body weight, skin folds and the serum levels of thyrotropic hormone, tetraiodothyroxine, prolactin, follicle...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Baptista T,Alastre T,Contreras Q,Martinez JL,Araujo de Baptista E,Burguera JL,de Burguera M,Hernández L

更新日期：1997-08-01 00:00:00

abstract：:1. Cerebral blood flow of nine methamphetamine abusers with technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and single photon emission computed tomography (SPECT) as well as morphological examination with magnetic resonance imaging (MRI) were investigated. 2. Six of these subjects exhibited multiple focal perfus...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Iyo M,Namba H,Yanagisawa M,Hirai S,Yui N,Fukui S

更新日期：1997-07-01 00:00:00

abstract：:1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Walden J,von Wegerer J,Winter U,Berger M,Grunze H

更新日期：1997-05-01 00:00:00

abstract：:1. In vertebrates as in invertebrates, protein kinase C appears to have a key role in learning and memory, probably given its involvement in synaptic plasticity. 2. Hippocampal PKC in mammalians is activated by learning in a large variety of memory tasks. However, the kind of information processed, the type of task, a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Noguès X

更新日期：1997-04-01 00:00:00

abstract：:1. The authors used transcranial magnetic stimulation (TMS) of pre-frontal cortex to study mood changes in 10 depressed patients and 10 schizophrenic patients. 2. A slow rate of stimuli was used, one per 30 seconds; maximal intensity of about 2 Tesla was given for 30 stimuli, 15 on each side of the brain. 3. No side e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Geller V,Grisaru N,Abarbanel JM,Lemberg T,Belmaker RH

更新日期：1997-01-01 00:00:00

abstract：:1. The authors studied the correlations between plasma concentrations of trazodone and mCPP at steady state and those after an initial dose of trazodone. 2. Fifteen depressed patients received trazodone 150 mg at bedtime for 3 weeks, and blood samplings were taken 12 h after the initial dose and 12 h after the last do...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Otani K,Mihara K,Yasui N,Ishida M,Kondo T,Tokinaga N,Ohkubo T,Osanai T,Sugawara K,Kaneko S

更新日期：1997-01-01 00:00:00

abstract：:1. Cyclothymia is characterized by pronounced but not debilitating shifts of moods often lasting approximately two to nine weeks. 2. It can be classified as a psychopathologic mood disorder on a continuum to Bipolar II, or as a chronobiologic rhythm similar to the circadian except on an infradian time scale. 3. A male...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Goodman DA

更新日期：1996-11-01 00:00:00

abstract：:1. Physical dependence and cross-physical dependence on barbital of the benzodiazepine receptor partial agonist S-(+)-DN-2327 and the benzodiazepine receptor full agonist diazepam were compared in male Fischer 344 rats. 2. In the physical dependence study, rats were treated with S-(+)-DN-2327 (30, 100, 300 and 1000 mg...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Inui Y,Yamamoto M,Awasaki Y,Nishida N

更新日期：1996-10-01 00:00:00

abstract：:1. The authors recently reported that acutely ill depressed adolescents have elevated plasma T4 and fT4 compared to controls. Studies in adult depression suggest antidepressant response is associated with decreases in these elevated levels. The effect of antidepressant treatment on adolescent thyroid indices has not b...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sokolov ST,Kutcher SP,Joffe RT

更新日期：1996-08-01 00:00:00

abstract：:1. After pretraining in an undrugged state, young (6 months) and aged (18-24 months) rats were trained on a spatial learning-set task after receiving one of four doses of diazepam (1, 2, 3 or 5 mg/kg) or the drug vehicle. The effects of 5 mg/kg of diazepam were also assessed on the spatial learning-set task one full h...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： McNamara RK,Davis TM,Skelton RW

更新日期：1996-07-01 00:00:00

abstract：:1. In extensively washed synaptic membrane preparations from rat prefrontal cortex, the "in vitro" addition of either the D1 (SKF 38393) or the D2 (LY 171555) specific agonists markedly decreased the apparent affinity of the NMDA receptor antagonist [3H]-MK801 specific binding. In the same membrane preparation, the co...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gandolfi O,Dall'Olio R

更新日期：1996-05-01 00:00:00